Diabetes insipidus is a condition in which a person is unable to produce sufficient levels of the hormone ADH. The hormone increases the permeability to water of the second (distal) convoluted tubule and collecting duct in the kidney nephrons. What is produced as a result?
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If the walls of the collecting duct are water-permeable, water leaves the ducts to pass into the hyperosmotic surrounding and concentrated urine is produced. Thus, when there is insufficient
, less water is reabsorbed and more dilute urine is produced in copious amounts.
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