DNA is a polymer of nucleotides which are linked to each other by 
phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose?
group in deoxyribose and
group with some other group in deoxyribose
Text Solution
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Two nucleotides are linked through 
phosphodiester linkage to form a dinucleotide. More nucleotides can be joined in such manner to form polynucleotide chain. A polymer thus formed has at one end a free phosphate moiety at 
end of sugar, which is referred to as 
of polynucleotide chain. Similarly at the other end of the polymer the sugar has a free OH of 
group which is referred to as of 
-end of the polynuclcotide chain. So, if we remove the OH group from 
end then further polymerization will not occur.
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