The sixth mutant codon of beta globin gene causing polymerization of Haemoglobin and change in RBC shape is 
.
Text Solution
Verified by ExpertsC
Normal Condition: The DNA codon is GAG, which codes for Glutamic acid.
• Mutant Condition: A point mutation changes the DNA codon to GUG, which codes for Valine.
• Result: This single amino acid substitution at the sixth position of the 
-globin chain causes hemoglobin molecules to polymerise under low oxygen, turning RBCs into a sickle shape.
──────────────────────────────────────────────────────────────────────────────────────────
Prepare Smarter with CGP Edu
Get practice questions, solutions, and test series in one place.
Write a Review
Share your experience with this question and solution.
Commentary
Send your comment, doubt, correction, or feedback to admin.
Similar Questions
Explore conceptually related problems