The nucleocytoplasmic (N/C) ratio = volume of nucleus volume of cytoplasm. As the cell grows (in and ), cytoplasm increases faster than the nucleus, so the N/C ratio decreases. Just after cytokinesis, new daughter cells are small with relatively less cytoplasm but the nucleus is of standard size → so the N/C ratio is highest at this stage.
Late phase → Cell has grown, cytoplasm increased → N/C ratio lower.
phase Cell is largest in phase ratio is low.
Prophase → Still large cell, nucleus about to dissolve → ratio is low.
Daughter cells formed just after cytokinesis → Small cells, cytoplasm minimum → N/C ratio highest.

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