The catalytic cycle of an enzyme action can be described in the following steps. Arrange them in sequence accordingly.

(1) The binding of the substrate induces the enzyme to alter its shape, fitting more tightly around the substrate.

(2) The substrate binds to the active site of the enzyme, fitting into the active site.

(3) The enzyme releases the products of the reaction and the free enzyme is ready to bind to another molecule of the substrate and run through the catalytic cycle once again.

(4) The active site of the enzyme, now in close proximity of the substrate breaks the chemical bonds of the substrate and the new enzyme product complex is formed.