The given statements are the steps in one type of gene ther…

Biology Biotechnology and Its Application Statement Based Questions Single Correct MCQ

Published by: CGP EDU Academic Team

Published on: August 21, 2026

The given statements are the steps in one type of gene therapy.

(i) Inject engineered cells into patients bone marrow.

(ii) Viral DNA carring the normal allele inserts into chromosome.

(iii) Let retrovirus infect bone marrow cells that have removed from patient and cultured.

(iv) Insert RNA version of normal allele into retrovirus.

(i), (ii), (iii) and (iv)

(iv), (iii), (ii) and (i)

(i), (ii), (iv) and (iii)

(iv), (iii), (i) and (ii)

Text Solution

Verified by Experts

The correct answer is:

In gene therapy (ADA deficiency), the correct sequence is:

(iv) Insert RNA version of the normal allele into a retrovirus.

(iii) Allow the retrovirus to infect bone marrow cells removed from the patient and cultured.

(ii) Viral DNA carrying the normal allele integrates into the chromosome of the host cell.

(i) Inject the engineered cells back into the patient's bone marrow.

Correct order: (iv) → (iii) → (ii) → (i)

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