In sickle-cell anaemia, glutamic acid is replaced by valine. Which one of the following triplet codes for valine?
Text Solution
Verified by ExpertsSickle-cell anaemia is an autosome linked recessive trait. This disease is controlled by a single pair of allele 
and 
; only the homozygous individuals for Hb , i.e., 
shows the diseased phenotype. The heterozygous individuals are carriers 
. Due to point mutation, glutamic acid (Glu) is replaced by valine (Val) at sixth position of 
-chain of haemoglobin molecule. This substitution occurs due to the single base substitution of the beta-globin gene from GAG (Glu) to GUG (Val).
Whereas, the other codes GGG, AAG, GAA do not codes for valine.
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