If a geneticist uses the blind approach of sequencing the whole set of genome that contained all the coding and noncoding sequence, and later assigning different regions in the sequence with functions, the methodology adopted by him is referred to as Sequence Annotation. For sequencing, the total DNA from a cell is isolated and converted into random fragments of relatively smaller sizes and cloned in suitable host using specialised vectors. The cloning resulted into amplification of each piece of DNA fragment so that it subsequently could be sequenced with ease.