Published by:
CGP EDU Academic Team
Published on: August 13, 2026
The reactivity of acid derivatives towards nucleophilic acyl substitution reactions decreases
in the order
A
Acid chloride 
anhydride 
ester 
amide
anhydride ester amide B
Acid chloride 
ester 
anhydride 
amide
ester anhydride amide C
Amide 
anhydride 
ester 
acid chloride
anhydride ester acid chloride D
Amide 
ester 
acid chloride 
anhydride
ester acid chloride anhydride
Text Solution
Verified by ExpertsThe correct answer is:
A
Acid chloride creates the strongest electrophilic center at carbonyl carbon, followed by
anhydride, ester, and amide, because 
shows -I-effect but all other show + -effect strongly.
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