A patient has a defective gene for the enzyme Adenosine Deaminase (ADA). He/She lacks functional cells and therefore, fails to fight the infecting pathogens. The cells are
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ADA deficiency causes Severe Combined Immunodeficiency (SCID), in which the immune system is severely impaired. The affected person lacks properly functioning:
• B-lymphocytes (responsible for antibody production)
• T-lymphocytes (responsible for cell-mediated immunity)
As a result, the body cannot effectively fight infections.
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