Statements related to human Insulin are given below. Which statement(s) is/are correct about genetically engineered Insulin?
(i) Pro-hormone insulin contain extra stretch of C-peptide
(ii) A-peptide and B-peptide chains of insulin were produced separately in E.coli, extracted and combined by creating disulphide bond between them.
(iii) Insulin used for treating Diabetes was extracted from Cattles and Pigs.
(iv) Pro-hormone Insulin needs to be processed for converting into a mature and functional hormone.
(v) Some patients develop allergic reactions to the foreign insulin.
Choose the most appropriate answer from the options given below:
Text Solution
Verified by ExpertsD
(i) True — Proinsulin has an extra C-peptide.
(ii) True — In recombinant insulin production, A and B chains are produced separately in E. coli and linked via disulfide bonds.
(iii) False — This is about earlier animal-derived insulin, not genetically engineered insulin.
(iv) True — Proinsulin must be processed to become active insulin.
(v) Not relevant to recombinant insulin focus in this question set (old animal insulin issue).
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