Neurotransmitter release would be significantly reduced due to the inability to trigger vesicle fusion. This is the correct outcome. When an action potential reaches the axon terminal, it triggers the opening of voltage-gated calcium channels. Calcium ions then flow into the cell and induce the synaptic vesicles to fuse with the presynaptic membrane, releasing their neurotransmitter contents into the synaptic cleft. If these channels are non-functional, calcium cannot enter the cell, and the vesicles cannot fuse with the membrane, which means that neurotransmitters cannot be released into the synaptic cleft.

──────────────────────────────────────────────────────────────────────────────────────────