Read the following and choose the option with all incorrect statements.

(I) The humoral- mediated immune response is responsible for graft rejection

(II) When immunity develops in host due to exposure to antigen, it is called active immunity and when immunity develops due to administration of ready- made antibodies, it is called passive immunity.

(III) The yellowish fluid colostrum secreted by mother during initial days of lactation has abundant antibodies IgG to protect infant.

(IV) The principle of vaccination is based on the property of memory of immune system.

(V) Using recombinant DNA technology, hepatitis A vaccine is produced from yeast.

(VI) The exaggerated response of immune system to certain antigens called allergens in the environment is known as allergy. The antibody produced in such response are IgE type.

(VII) Allergy is due to release of chemicals like histamine and serotonin from the mast cells.

(VIII) The use of drug like anti- histamine, adrenalin and steroids quickly reduces symptoms of allergy.

(IX) Memory based innate immunity is evolved in vertebrate.

(X) Rheumatoid arthritis is an example of auto immune response.

(XI) The primary lymphoid organs in our body are bone marrow and thymus.

(XII) After maturation, the lymphocyte are lymphoid organs where interaction of lymphocyte with antigen occur.

(XIII) Spleen organ has a large reservoir of leukocytes.