Haemozoin is a toxin released by Plasmodium species, which is responsible for the chill and high fever recurring every three to four days.
To continue their life-cycle, Plasmodium enters the human body as sporozoites and multiply within the liver cells, resulting in the rupture of the RBCs.
The rupture RBCs is associated with release of a toxic substance, haemozoin, while Streptococcus produces streptomycin and streptococcal pyrogenic exotoxin which shows haemolytic and Haemophilus produces cytolethal distending toxin (HdCDT) which inhibit mammals cell proliferation.